Handling and performance wise the are equal. Maybe not on a track but certainly on public roads.
There is now a V4 Tuono so the gen1 Tuono is now 2 generations old. Not a problem if you dont mind.
I would say the gen1 is a little more reliable as they have less complicated electronics and a better generator setup. Having said that, that certainly would not stop me from
buying a gen2 Tuono.
From what I understand the gen1 is a bit more comfortable.